Neurobiology of Disease SIRT1 Protects against -Synuclein Aggregation by Activating Molecular Chaperones
نویسندگان
چکیده
Gizem Donmez,1 Anirudh Arun,1 Chee-Yeun Chung,3 Pamela J. McLean,2 Susan Lindquist,3 and Leonard Guarente1 1Paul F. Glenn Laboratory and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, 2Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, and 3Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
منابع مشابه
SIRT1 protects against α-synuclein aggregation by activating molecular chaperones.
α-Synuclein is a key molecule in the pathogenesis of synucleinopathy including dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. Sirtuins are NAD(+)-dependent protein deacetylases that are highly conserved and counter aging in lower organisms. We show that the life span of a mouse model with A53T α-synuclein mutation is increased by overexpressing SIRT1 and decreased ...
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تاریخ انتشار 2011